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Phase-separated polymer blends for controlled drug delivery by tuning morphology

Chemistry

Phase-separated polymer blends for controlled drug delivery by tuning morphology

M. Olsson, R. Storm, et al.

This study reveals a groundbreaking formulation strategy utilizing phase-separated polymer blends to precisely control drug release rates while enhancing the stability of active pharmaceutical ingredients in oral solid dosage forms. Conducted by a team of experts including Martina Olsson and Robin Storm, this research explores the creation of porous networks that dictate release characteristics, shedding light on the relationship between morphology and drug release.

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Playback language: English
Abstract
This study demonstrates a formulation strategy using phase-separated polymer blends to control drug release rate and provide stability to the active pharmaceutical ingredient in oral solid dosage forms. By using a hydrophobic polymer (PLA) and a hydrophilic polymer (HPMC), a porous network is created upon dissolution, dictating release characteristics. Ptychographic X-ray tomography and scanning transmission X-ray microscopy reveal how morphology depends on polymer fraction and drug presence. The correlation between morphology and drug release is showcased, highlighting the potential for tuning polymer matrix morphology for controlled drug release.
Publisher
Communications Materials
Published On
Oct 18, 2024
Authors
Martina Olsson, Robin Storm, Linnea Björn, Viktor Lilja, Leonard Krupnik, Yang Chen, Polina Naidjonoka, Ana Diaz, Mirko Holler, Benjamin Watts, Anette Larsson, Marianne Liebi, Aleksandar Matic
Tags
drug release
polymer blends
oral solid dosage
morphology
X-ray microscopy
formulation strategy
active pharmaceutical ingredient
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