This study utilizes data from the REACT-2 study (n=606,434) to estimate the prevalence and identify predictors of persistent COVID-19 symptoms lasting 12 weeks or more in England. At 12 weeks, 37.7% experienced at least one symptom (rounds 3–5), decreasing to 21.6% in round 6. Female sex, older age, obesity, smoking, vaping, COVID-19 hospitalization, deprivation, and being a healthcare worker were associated with higher probabilities of persistent symptoms. Clustering analysis identified a subset with predominantly respiratory symptoms. Managing long-term sequelae remains a major challenge.
Publisher
NATURE COMMUNICATIONS
Published On
Apr 12, 2022
Authors
Matthew Whitaker, Joshua Elliott, Marc Chadeau-Hyam, Steven Riley, Ara Darzi, Graham Cooke, Helen Ward, Paul Elliott
Tags
COVID-19
persistent symptoms
England
predictors
healthcare workers
obesity
deprivation
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