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Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Medicine and Health

Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

G. Ocana-santero, H. Warming, et al.

Serotonin shapes early neocortical development; this longitudinal imaging study shows that genetic deletion of the serotonin transporter, perinatal antidepressant exposure, and aversive experience each elevate neonatal cortical serotonin, alter GABAergic microcircuits and switch cortical activity with lasting effects on sensory encoding. Research was conducted by the authors listed in the <Authors> tag.

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~3 min • Beginner • English
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