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Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

Medicine and Health

Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

C. Sun, Y. Kang, et al.

Explore the fascinating evolution of SARS-CoV-2 variants, including Omicron, which have taken immune escape to new heights! This groundbreaking research by Cong Sun and colleagues employs computational interface analysis and in vitro assays to profile critical mutations affecting antibody neutralization. Uncover the insights that guide the future of neutralizing antibody therapy.

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Playback language: English
Abstract
SARS-CoV-2 variants have evolved critical mutations causing antigenicity changes and immune escape. This study profiles Omicron and other variants using computational interface analysis and in vitro assays. Critical mutations impacting 14 antibodies' neutralization efficiency were identified, revealing diverse molecular mechanisms. Omicron showed exceptional immune escape potency. The study highlights computational interface analysis for SARS-CoV-2 mutation surveillance and early identification of concerning variants, guiding neutralizing antibody therapy.
Publisher
Signal Transduction and Targeted Therapy
Published On
Feb 08, 2022
Authors
Cong Sun, Yin-Feng Kang, Yuan-Tao Liu, Xiang-Wei Kong, Hui-Qin Xu, Dan Xiong, Chu Xie, Yi-Hao Liu, Sui Peng, Guo-Kai Feng, Zheng Liu, Mu-Sheng Zeng
Tags
SARS-CoV-2
variants
Omicron
immune escape
neutralization efficiency
antibody therapy
computational analysis

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