Chemistry
Oxidative photocatalysis on membranes triggers non-canonical pyroptosis
C. Lee, M. Park, et al.
This groundbreaking research by Chaiheon Lee, Mingyu Park, W. C. Bhashini Wijesinghe, and their colleagues reveals how oxidative stress targeting intracellular membranes leads to significant cellular responses, including activation of non-canonical inflammasome caspases and pyroptosis. A pivotal look at the damaging effects of oxidative processes on membrane proteins sheds light on mitochondrial and endoplasmic reticulum stress, opening new avenues for understanding cell death mechanisms.
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