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Abstract
This study investigates the role of orexin-A/hypocretin-1 and endocannabinoid 2-arachidonoylglycerol signaling in obesity-associated hippocampal dysfunction. The researchers demonstrate that excessive orexin-A/2-arachidonoylglycerol/cannabinoid receptor type-1 signaling leads to impaired adult hippocampal neurogenesis, reduced plasticity, and impaired pattern separation, impacting episodic memory. Inhibiting orexin-A action at orexin-1 receptors rescued these deficits, providing a molecular mechanism for episodic memory alterations in obesity.
Publisher
NATURE COMMUNICATIONS
Published On
Oct 21, 2021
Authors
Nicola Forte, Serena Boccella, Lea Tunisi, Alba Clara Fernández-Rilo, Roberta Imperatore, Fabio Arturo Iannotti, Maria De Risi, Monica Iannotta, Fabiana Piscitelli, Raffaele Capasso, Paolo De Girolamo, Elvira De Leonibus, Sabatino Maione, Vincenzo Di Marzo, Luigia Cristino
Tags
obesity
hippocampal dysfunction
orexin-A
endocannabinoids
neurogenesis
memory
pattern separation

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