logo
ResearchBunny Logo
Abstract
The Omicron variant of SARS-CoV-2 rapidly replaced previous variants, exhibiting increased transmissibility. This study investigates Omicron's enhanced infectivity and interferon resistance in human nasal tissue. Using recombinant SARS-CoV-2 and nasal epithelial cells, researchers found that Omicron's unique Spike mutations facilitated enhanced entry into nasal tissue, independent of serine transmembrane proteases but reliant on metalloproteinases. This entry pathway enabled evasion of antiviral factors, contributing to Omicron's increased transmissibility.
Publisher
Nature Communications
Published On
Jan 30, 2024
Authors
Guoli Shi, Tiansheng Li, Kin Kui Lai, Reed F. Johnson, Jonathan W. Yewdell, Alex A. Compton
Tags
Omicron variant
SARS-CoV-2
transmissibility
nasal tissue
interferon resistance
Spike mutations

Related Publications

Explore these studies to deepen your understanding of the subject.

Human antibodies to SARS-CoV-2 with a recurring YYDRXG motif retain binding and neutralization to variants of concern including Omicron
Medicine and Health

Human antibodies to SARS-CoV-2 with a recurring YYDRXG motif retain binding and neutralization to variants of concern including Omicron

H. Liu, C. I. Kaku, et al.

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)
Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells
Medicine and Health

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

W. Hong, J. Yang, et al.

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
Medicine and Health

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L. Zhang, C. B. Jackson, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny