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Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

Medicine and Health

Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

G. Shi, T. Li, et al.

Discover the fascinating findings of Guoli Shi and colleagues as they delve into the Omicron variant of SARS-CoV-2. This research uncovers how Omicron's unique Spike mutations enhance its ability to invade human nasal tissue, evading antiviral defenses and contributing to its rapid spread. Don't miss out on these groundbreaking insights!

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Playback language: English
Abstract
The Omicron variant of SARS-CoV-2 rapidly replaced previous variants, exhibiting increased transmissibility. This study investigates Omicron's enhanced infectivity and interferon resistance in human nasal tissue. Using recombinant SARS-CoV-2 and nasal epithelial cells, researchers found that Omicron's unique Spike mutations facilitated enhanced entry into nasal tissue, independent of serine transmembrane proteases but reliant on metalloproteinases. This entry pathway enabled evasion of antiviral factors, contributing to Omicron's increased transmissibility.
Publisher
Nature Communications
Published On
Jan 30, 2024
Authors
Guoli Shi, Tiansheng Li, Kin Kui Lai, Reed F. Johnson, Jonathan W. Yewdell, Alex A. Compton
Tags
Omicron variant
SARS-CoV-2
transmissibility
nasal tissue
interferon resistance
Spike mutations

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