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NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation
BiologyNature Communications

NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation

S. Dodt, N. V. Widdershooven, et al.

Fasting reshapes hypothalamic circuits: the orexigenic peptide NPY drives input-specific synaptic plasticity in the BNST—strengthening AgRP (hunger) GABAergic inputs while weakening CeA (anxiety-related) inputs—to shift the balance toward feeding. These adaptations, evoked by AgRP neuron activation, are absent in NPY-deficient mice, linking NPY to coordinated changes in hunger and anxiety during starvation. This research was conducted by Authors present in <Authors> tag.... show more
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