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Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing
Medicine and HealthNutrition & Diabetes

Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing

Y. Huang, P. Qin, et al.

This groundbreaking study by Yating Huang and colleagues explores the powerful synergy between intermittent fasting and pulsed radiofrequency energy in enhancing diabetic wound healing. The findings reveal that this innovative combination therapy significantly boosts healing processes, including proliferation and angiogenesis, offering new hope for diabetic patients.... show more
GeneralSummaryMetrics
Abstract
OBJECTIVE: This study aims to conduct an unbiased assessment of the synergistic effects of non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy on the facilitation of diabetic wound healing, while also exploring the underlying mechanisms. METHODS: In vivo, diabetes was induced in C57 mice with streptozotocin, wounds were created, and mice underwent fasting on days 2 and 6 with twice-daily PRFE for 8 days; in vitro, serum-free culture simulated fasting. Wound healing rate, proliferation, migration, angiogenesis, oxidative stress, fibrogenesis, and sensory nerve growth were assessed via histology and functional assays; qRT-PCR, western blotting, and immunofluorescence were used to explore mechanisms. RESULTS: The intermittent fasting and PRFE combination therapy outperformed either monotherapy, promoting migration, reducing oxidative stress, and enhancing fibrogenesis, and showed synergistic effects on proliferation, tube formation/angiogenesis, and sensory nerve growth. CONCLUSION: Intermittent fasting plus PRFE enhances diabetic wound healing by leveraging complementary strengths and synergistic benefits, with potential involvement of the P75/HIF1A/VEGFA axis.
Publisher
Nutrition & Diabetes
Published On
Oct 07, 2024
Authors
Yating Huang, Peiliang Qin, Peng Zhou, Binbin Long, Shan Zhang, Ruikang Gao, Bingjie Zhu, Yiqing Li, Qin Li
DOI
https://doi.org/10.1038/s41387-024-00344-9
Tags
intermittent fastingpulsed radiofrequency energydiabetic wound healingangiogenesisoxidative stressfibrogenesisP75/HIF1A/VEGFA axis
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