Medicine and Health

Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines

W. Zhu, T. Wei, et al.

This research by Wenjun Zhu and colleagues unveils an innovative transdermal delivery system using fluorocarbon-modified chitosan, significantly enhancing the non-invasive transport of biomacromolecules. Demonstrating efficacy in various applications, the platform shows promise for safer and more effective delivery of therapeutics.

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Abstract

This research paper introduces a novel transdermal delivery platform based on fluorocarbon-modified chitosan (FCS) for efficient non-invasive delivery of biomacromolecules. The FCS nanocomplexes effectively penetrate the skin via intercellular and transappendageal routes. In melanoma-bearing mice, transdermal delivery of immune checkpoint blockade antibodies induced stronger immune responses and reduced systemic toxicity compared to intravenous injection. Transdermal delivery of a SARS-CoV-2 vaccine also resulted in comparable humoral immunity and improved cellular immunity and immune memory. The platform demonstrated efficacy in rabbit and porcine skin models, suggesting broad applicability for delivering biotherapeutics.

Publisher

Nature Communications

Published On

Jan 27, 2024

Authors

Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen, Zhuang Liu

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