Medicine and Health

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

C. Moritz, E. C. Field-fote, et al.

This innovative trial assessed the potential of ARCEX Therapy, combining spinal cord stimulation with rehabilitation, to enhance upper limb functionality in individuals with chronic tetraplegia. With a remarkable 72% of participants showing meaningful improvement, this research led by Chet Moritz and colleagues highlights a significant leap forward in rehabilitation techniques.

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Index

Abstract

This prospective, single-arm, multicenter, open-label trial evaluated the safety and efficacy of ARCEX Therapy (cervical spinal cord electrical stimulation during structured rehabilitation) to improve arm and hand functions in chronic tetraplegia. Sixty participants completed the protocol. No serious adverse events related to ARCEX Therapy were reported. 72% of participants showed improvements exceeding minimally important difference criteria for both strength and functional performance. Secondary endpoints showed significant improvements in fingertip pinch force, hand prehension and strength, upper extremity motor and sensory abilities, and self-reported quality of life.

Publisher

Nature Medicine

Published On

May 20, 2024

Authors

Chet Moritz, Edelle C. Field-Fote, Candace Tefertiller, Ilse van Nes, Randy Trumbower, Sukhvinder Kalsi-Ryan, Mariel Purcell, Thomas W. J. Janssen, Andrei Krassioukov, Leslie R. Morse, Kristin D. Zhao, James Guest, Ralph J. Marino, Lynda M. Murray, Jill M. Wecht, Markus Rieger, Jared Pradarelli, Amanda Turner, Jessica D’Amico, Jordan W. Squair, Gregoire Courtine

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