This prospective, single-arm, multicenter, open-label trial evaluated the safety and efficacy of ARCEX Therapy (cervical spinal cord electrical stimulation during structured rehabilitation) to improve arm and hand functions in chronic tetraplegia. Sixty participants completed the protocol. No serious adverse events related to ARCEX Therapy were reported. 72% of participants showed improvements exceeding minimally important difference criteria for both strength and functional performance. Secondary endpoints showed significant improvements in fingertip pinch force, hand prehension and strength, upper extremity motor and sensory abilities, and self-reported quality of life.
Publisher
Nature Medicine
Published On
May 20, 2024
Authors
Chet Moritz, Edelle C. Field-Fote, Candace Tefertiller, Ilse van Nes, Randy Trumbower, Sukhvinder Kalsi-Ryan, Mariel Purcell, Thomas W. J. Janssen, Andrei Krassioukov, Leslie R. Morse, Kristin D. Zhao, James Guest, Ralph J. Marino, Lynda M. Murray, Jill M. Wecht, Markus Rieger, Jared Pradarelli, Amanda Turner, Jessica D’Amico, Jordan W. Squair, Gregoire Courtine
Tags
ARCEX Therapy
chronic tetraplegia
spinal cord stimulation
upper limb function
rehabilitation
safety
efficacy
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