Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice

Meningeal lymphatic vessels (mLVs) are involved in amyloid beta (Aβ) clearance, a potential therapeutic target for Alzheimer's disease (AD). This study uses near-infrared light to modulate lymphatic drainage, improving cognition in aged and AD mice and reducing Aβ deposition, neuroinflammation, and neuronal damage. Transmission electron microscopy and RNA sequencing showed improved mitochondrial metabolism and cellular junctions in meningeal lymphatic endothelial cells (mLECs). Near-infrared light treatment improves cognitive function by strengthening mLVs' scavenging ability via restored mLEC function, offering a potential amelioration strategy for neurodegenerative diseases.

Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou