Medicine and Health

Non-invasive brain stimulation in cognitive sciences and Alzheimer's disease

C. Carrarini, C. Pappalettera, et al.

Non-invasive brain stimulation modalities (TMS, tES, TUS) are reshaping cognitive neuroscience and dementia care by modulating neural networks and supporting individualized neuromodulation strategies. This review summarizes physiological and technical mechanisms and clinical applications—particularly in Alzheimer’s disease—and advocates integrating NIBS within multidisciplinary translational care to potentially improve cognitive outcomes. This research was conducted by Claudia Carrarini, Chiara Pappalettera, Domenica Le Pera, and Paolo Maria Rossini.

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~3 min • Beginner • English

Index

Abstract

Over the last four decades, non-invasive brain stimulation (NIBS) has gained traction in cognitive science and dementia care for probing brain function and enhancing residual cognition. This review outlines physiological and technical mechanisms and clinical applications of major NIBS modalities—transcranial magnetic stimulation (TMS), transcranial electrical stimulation (tES), and transcranial ultrasound stimulation (TUS)—highlighting their roles in cognitive neuroscience and neurorehabilitation, especially in Alzheimer’s disease (AD). Evidence suggests NIBS can modulate neural networks, support individualized neuromodulation strategies, and potentially improve cognitive outcomes when integrated within multidisciplinary, translational care frameworks.

Publisher

Frontiers in Human Neuroscience

Published On

Jan 14, 2025

Authors

Claudia Carrarini, Chiara Pappalettera, Domenica Le Pera, Paolo Maria Rossini

DOI

https://doi.org/10.3389/fnhum.2024.1500502

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