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Abstract
This study investigates the AKT serine/threonine kinase-dependent epigenetic control of ACE2 and TMPRSS2 expression by high-cannabidiol (CBD) cannabis extracts. High-CBD cannabis extracts and their components downregulated ACE2 and TMPRSS2 in lung fibroblast WI-38 cells through AKT-mediated inhibition. miR-200c-3p and let-7a-5p contributed to this suppression. The extracts also suppressed COX2 expression and attenuated TNFα/IFNγ-triggered inflammation. These findings suggest that high-CBD cannabis extracts may have potential anti-COVID-19 properties.
Publisher
Cell Death Discovery
Published On
Mar 11, 2022
Authors
Bo Wang, Dongping Li, Anna Fiselier, Igor Kovalchuk, Olga Kovalchuk
Tags
CBD
cannabis extracts
ACE2
TMPRSS2
AKT
inflammation
anti-COVID-19

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