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NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

Medicine and Health

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

X. Zhang, X. Huang, et al.

This groundbreaking study reveals how NEK2 kinase phosphorylates PD-L1, hindering the impact of PD-L1-targeted immunotherapy in pancreatic cancer. The authors discovered that inhibiting NEK2 improves lymphocyte infiltration and enhances the immune response, offering a novel strategy for advancing pancreatic cancer treatment.

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