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Mycobacterial Hsp65 antigen delivered by invasive *Lactococcus lactis* reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model

Medicine and Health

Mycobacterial Hsp65 antigen delivered by invasive *Lactococcus lactis* reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model

V. P. D. Cunha, T. M. Preisser, et al.

In a groundbreaking study, researchers explored the potential of Hsp65-producing *Lactococcus lactis* to combat intestinal fibrosis, a major complication of Crohn's disease. This innovative approach significantly decreased inflammation and fibrosis, showing promise for future treatments. This research was conducted by Vanessa Pecini da Cunha, Tatiane Melo Preisser, Mariana Passos Santana, Denise Carmona Cara Machado, Vanessa Bastos Pereira, and Anderson Miyoshi.

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Playback language: English
Abstract
Intestinal fibrosis is a serious complication of Crohn's disease (CD). Heat shock proteins (HSPs), which regulate effector T cells, may offer alternative treatment. This study evaluated the anti-inflammatory and antifibrotic effects of invasive, Hsp65-producing *Lactococcus lactis* NCDO2118 FnBPA+ (pXYCYT:Hsp65) in a chronic colitis model. Oral administration significantly attenuated inflammation and fibrosis, reducing pro-fibrotic cytokines IL-13 and TGF-β while increasing regulatory cytokine IL-10. This confirms the potential of this strategy for treating fibrotic CD.
Publisher
Scientific Reports
Published On
Nov 18, 2020
Authors
Vanessa Pecini da Cunha, Tatiane Melo Preisser, Mariana Passos Santana, Denise Carmona Cara Machado, Vanessa Bastos Pereira, Anderson Miyoshi
Tags
Crohn's disease
intestinal fibrosis
Hsp65
Lactococcus lactis
anti-inflammatory
cytokines

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