Intestinal fibrosis is a serious complication of Crohn's disease (CD). Heat shock proteins (HSPs), which regulate effector T cells, may offer alternative treatment. This study evaluated the anti-inflammatory and antifibrotic effects of invasive, Hsp65-producing *Lactococcus lactis* NCDO2118 FnBPA+ (pXYCYT:Hsp65) in a chronic colitis model. Oral administration significantly attenuated inflammation and fibrosis, reducing pro-fibrotic cytokines IL-13 and TGF-β while increasing regulatory cytokine IL-10. This confirms the potential of this strategy for treating fibrotic CD.
Publisher
Scientific Reports
Published On
Nov 18, 2020
Authors
Vanessa Pecini da Cunha, Tatiane Melo Preisser, Mariana Passos Santana, Denise Carmona Cara Machado, Vanessa Bastos Pereira, Anderson Miyoshi
Tags
Crohn's disease
intestinal fibrosis
Hsp65
Lactococcus lactis
anti-inflammatory
cytokines
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