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Abstract
Copy number variants (CNVs) at 16p11.2 and 22q11.2 loci are associated with neuropsychiatric disorders. This study analyzed resting-state functional connectivity (FC) in CNV carriers, individuals with idiopathic ASD, SZ, or ADHD, and controls. CNVs showed mirror effects on FC. Thalamus, somatomotor, and posterior insula regions showed dysconnectivity across deletions, duplications, idiopathic ASD, and SZ but not ADHD. Higher similarity to deletion FC-signatures correlated with worse cognitive and behavioral symptoms. Results suggest shared dysconnectivity dimensions across seemingly distinct genetic variants and idiopathic disorders.
Publisher
Nature Communications
Published On
Oct 19, 2020
Authors
Clara A. Moreau, Sebastian G. W. Urchs, Kumar Kuldeep, Pierre Orban, Catherine Schramm, Guillaume Dumas, Aurélie Labbé, Guillaume Huguet, Elise Douard, Pierre-Olivier Quirion, Amy Lin, Leila Kushan, Stephanie Grot, David Luck, Adrianna Mendrek, Stephane Potvin, Emmanuel Stip, Thomas Bourgeron, Alan C. Evans, Carrie E. Bearden, Pierre Bellec, Sebastien Jacquemont
Tags
copy number variants
neuropsychiatric disorders
functional connectivity
ASD
SZ
dysconnectivity
cognitive symptoms

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