This study investigated the preventative effects of music on stress-induced depression and anxiety-like behaviors in mice. Mice were subjected to chronic unpredictable mild stress (CUMS) during the day and exposed to music at night. Results showed that music completely prevented CUMS-induced depression and anxiety-like behaviors, as measured by various behavioral tests. Music also restored serum corticosterone levels, BDNF and Bcl-2 levels, and prevented CUMS-induced oxidative stress and inflammatory responses in the serum, prefrontal cortex, and hippocampus.
