This study investigated natural populations of two reef-building coral genera (*Pocillopora* spp. and *Porites* spp.) and one hydrocoral (*Millepora* cf. *platyphylla*) from the Pacific Ocean using a multi-omics approach. A standardized method involving biphasic extraction and mass spectrometry/NMR analysis identified 24 compounds by NMR and over 200 lipids by MS. Metabolic profiles were distinct among genera but not within genotypes, suggesting a combined effect of holobiont members and environmental interaction.

Maggie M. Reddy, Corentine Goossens, Yuxiang Zhou, Slimane Chaib, Delphine Raviglione, Florence Nicolès, Benjamin C. C. Hume, Didier Forcioli, Sylvain Agostini, Emilie Boissin, Emmanuel Boss, Chris Bowler, Colomban de Vargas, Eric Douville, Michel Flores, Paola Furla, Pierre E. Galand, Eric Gilson, Fabien Lombard, Stéphane Pesant, Stéphanie Reynaud, Matthew B. Sullivan, Shinichi Sunagawa, Romain Troublé, Rebecca Vega Thurber, Patrick Wincker, Didier Zoccola, Christian R. Voolstra, Denis Allemand, Serge Planes, Olivier P. Thomas, Bernard Banaigs