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Abstract
This study investigated the role of CXCL12 in breast cancer using integrative multi-omics analyses. High CXCL12 expression was associated with prolonged survival. A prognostic signature was built using 11 CXCL12-related genes (VAT1L, TMEM92, SDC1, RORB, PCSK9, NRN1, NACAD, JPH3, GJA1, BMP8B, and ADAMTS2), which effectively predicted patient outcomes. High-risk patients showed increased M2-like macrophage infiltration and different drug sensitivities. The study suggests CXCL12-related biomarkers could guide breast cancer diagnosis and treatment.
Publisher
Frontiers in Immunology
Published On
Jul 26, 2023
Authors
Zhi-Jie Gao, Zhou Fang, Jing-Ping Yuan, Sheng-Rong Sun, Bei Li
Tags
CXCL12
breast cancer
prognostic signature
multi-omics
macrophage infiltration
biomarkers
patient outcomes

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