Medicine and Health

Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue

L. Yan, L. Wang, et al.

This research by Liang Yan and colleagues explores innovative graphene oxide/poly-L-lactic acid nanofiber scaffolds that enhance ovarian function in mice with primary ovarian insufficiency. This study not only advances tissue engineering but also presents a fresh approach to organ transplantation and cryopreservation.

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Abstract

This study successfully constructed graphene oxide/poly-L-lactic acid (GO/PLLA) nanofiber scaffolds with a hydrophilic surface and porous network structure, promoting cell infiltration, graft tissue survival, and angiogenesis. A 1.0 wt% GO/PLLA scaffold improved the fusion of transplanted ovarian cortex with damaged ovarian tissue in mice with primary ovarian insufficiency (POI), enhancing ovarian function and follicle numbers. Angiogenesis was observed, and nitric oxide (NO) production by phosphorylated endothelial nitric oxide synthase (p-eNOS) was implicated in the improved survival rate. This offers a new method for ovarian tissue cryopreservation and transplantation and a potential strategy for other organ transplants.

Publisher

npj Regenerative Medicine

Published On

Sep 16, 2022

Authors

Liang Yan, Lingjuan Wang, Jiachen Wu, Yuanzheng Wu, Xianyu Zhu, Qiaojuan Mei, Yinhua Song, Yang Liu, Ling Zhang, Jihui Ai, Kezhen Li, Guangming Qing, Yong Zhang, Xianjin Xiao, Yuliang Zhao, Wenpei Xiang

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