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Abstract
This research paper investigates the role of mitochondrial-encoded MOTS-c in regulating age-dependent physical decline and muscle homeostasis. The study demonstrates that MOTS-c enhances physical performance in mice of various ages and that exercise induces MOTS-c expression in humans. Furthermore, it shows that late-life MOTS-c treatment improves physical capacity and healthspan in mice, suggesting a potential therapeutic target for age-related decline.
Publisher
Nature Communications
Published On
Jan 20, 2021
Authors
Joseph C. Reynolds, Rochelle W. Lai, Jonathan S. T. Woodhead, James H. Joly, Cameron J. Mitchell, David Cameron-Smith, Ryan Lu, Pinchas Cohen, Nicholas A. Graham, Bérénice A. Benayoun, Troy L. Merry, Changhan Lee
Tags
MOTS-c
age-related decline
physical performance
muscle homeostasis
therapeutic target
healthspan
exercise

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