Medicine and Health

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

M. Koehler, A. Ray, et al.

This cutting-edge study reveals how SARS-CoV-2 mutations, particularly N501Y and E484Q, modify receptor binding and antibody neutralization. By employing atomic force microscopy and molecular dynamics, the authors delve into the stability of the RBD-ACE2 complex, offering crucial insights into the variant's implications on immunity. This research was conducted by Melanie Koehler, Ankita Ray, Rodrigo A. Moreira, Blinera Juniku, Adolfo B. Poma, and David Alsteens.