Biology

Modular microfluidics enables kinetic insight from time-resolved cryo-EM

M. Mäeots, B. Lee, et al.

This groundbreaking research introduces a time-resolved sample preparation method using a modular microfluidic device, revolutionizing cryo-electron microscopy. Conducted by Märt-Erik Mäeots and colleagues, this technique allows for fast, automated, and blot-free sample vitrification, unveiling reaction intermediates of RecA filament growth on sub-second timescales, and showcasing its versatility for various biological inquiries.