Medicine and Health

Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation

K. Takeda, A. Uda, et al.

Discover how mitochondrial dynamics play a crucial role in Alzheimer's disease in this groundbreaking research led by Keisuke Takeda and colleagues. Their study reveals the downregulation of the mitochondrial ubiquitin ligase MITOL/MARCH5 in AD patients, exacerbating cognitive decline and mitochondrial dysfunction. This groundbreaking work links mitochondrial changes to increased toxic Aβ oligomer production, reshaping our understanding of AD pathogenesis.

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