Medicine and Health

Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson's disease

T. He, X. Lin, et al.

Discover groundbreaking insights into Parkinson's disease and the potential of natural products as therapeutic agents for mitochondrial dysfunction, as explored by Ting He, Xiaoyan Lin, Anping Su, Yujie Zhang, Zhichao Xing, Li Mi, Tao Wei, Zhihui Li, and Wenshuang Wu.

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Index

Abstract

Parkinson's disease (PD), a prevalent neurodegenerative disorder, involves complex pathogenesis including mitochondrial dysfunction and oxidative stress. Natural products, with diverse structures and bioactive components, represent a significant resource for developing small molecule PD drugs targeting mitochondrial dysfunction. This review, encompassing publications from 2012-2022, examines the mechanisms of various natural products in regulating PD-related mitochondrial dysfunction, highlighting their potential as therapeutic agents.

Publisher

Frontiers in Pharmacology

Published On

Apr 26, 2023

Authors

Ting He, Xiaoyan Lin, Anping Su, Yujie Zhang, Zhichao Xing, Li Mi, Tao Wei, Zhihui Li, Wenshuang Wu

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