Engineering and Technology

Microfluidic QCM enables ultrahigh Q-factor: a new paradigm for in-liquid gravimetric sensing

Y. Zhao, Z. Parlak, et al.

This groundbreaking research by Yicheng Zhao, Zehra Parlak, Wenjun Yu, Daniel French, Wilkins Aquino, and Stefan Zauscher presents a revolutionary microfluidic QCM that dramatically enhances the performance of acoustic gravimetric biosensors. With a remarkable 10-fold improvement in dissipation, this innovation paves the way for more sensitive and accurate gravimetric sensing, transforming data interpretation and enabling precise control over sample volumes and temperatures.

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Abstract

Acoustic gravimetric biosensors, while simple, robust, and low-cost, suffer from low quality factors (Q-factors) due to dissipation in liquid environments. This research introduces a microfluidic QCM (µ-QCM) that mitigates this by confining liquid in microchannels. Finite element analysis and dimensional studies revealed that the ratio of channel width to pressure wavelength (W/λp) and channel height to shear evanescent wavelength (H/λs) are key performance determinants. A fabricated µ-QCM demonstrated a 10-fold improvement in dissipation compared to conventional QCM, offering advantages in data interpretation, sample volume, and temperature control. This paradigm shift enhances sensitivity and accuracy for gravimetric sensing.

Publisher

Microsystems & Nanoengineering

Published On

Authors

Yicheng Zhao, Zehra Parlak, Wenjun Yu, Daniel French, Wilkins Aquino, Stefan Zauscher

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