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Metabolic preference assay for rapid diagnosis of bloodstream infections

Medicine and Health

Metabolic preference assay for rapid diagnosis of bloodstream infections

T. Rydzak, R. A. Groves, et al.

Bloodstream infections can be deadly, but researchers from the University of Calgary have developed a groundbreaking rapid metabolic preference assay that identifies pathogens and determines antibiotic susceptibility in under 20 hours. This innovation has the potential to save lives and optimize antibiotic treatment, marking a significant advancement over traditional diagnostic methods that take several days.

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Playback language: English
Abstract
Bloodstream infections (BSIs) pose a significant threat, causing substantial morbidity and mortality. Current diagnostic methods for identifying BSI pathogens and determining antimicrobial susceptibility take 2-5 days, contributing to delayed treatment and increased mortality. This paper introduces a rapid metabolic preference assay (MPA) that uses metabolic flux patterns in ex-vivo microbial cultures to identify common pathogens and determine antimicrobial susceptibility profiles within under 20 hours, significantly reducing testing timelines compared to existing methods like VITEK 2. This assay has the potential to reduce septic shock mortality and optimize antibiotic use.
Publisher
Nature Communications
Published On
Apr 28, 2022
Authors
Thomas Rydzak, Ryan A Groves, Ruichuan Zhang, Raied Aburashed, Rajnigandha Pushpker, Maryam Mapar, Ian A Lewis
Tags
bloodstream infections
diagnostics
antimicrobial susceptibility
metabolic preference assay
septic shock
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