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Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Medicine and Health

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

A. Y. L. Chan, L. Gao, et al.

This multinational cohort study reveals a small-to-moderate association between maternal diabetes mellitus and attention-deficit/hyperactivity disorder in offspring. Conducted by an extensive team of researchers, the findings emphasize the importance of further exploration into the roles of hyperglycemia and genetic factors in this relationship.

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Playback language: English
Abstract
This multinational cohort study investigated the association between maternal diabetes mellitus (MDM) and attention-deficit/hyperactivity disorder (ADHD) in offspring. Using data from over 3.6 million mother–child pairs, the study found a small-to-moderate association between MDM (including gestational and pregestational diabetes) and ADHD. However, sibling-matched analyses suggested that the association with gestational diabetes might be due to unmeasured shared familial factors. The findings highlight the need for further research to clarify the roles of hyperglycemia and genetic factors in the MDM-ADHD relationship.
Publisher
Nature Medicine
Published On
May 01, 2024
Authors
Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Carolyn E. Cesta, Edward Chia-Cheng Lai, Helga Zoega, Kenneth K. C. Man, Ian C. K. Wong
Tags
maternal diabetes mellitus
ADHD
offspring
gestational diabetes
hyperglycemia
genetic factors
multinational study

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