Biology

Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage

A. A. Saei, H. Gharibi, et al.

This study by Amir Ata Saei, Hassan Gharibi, Hezhe Lyu, Brady Nilsson, Maryam Jafari, Hans Von Holst, and Roman A Zubarev unveils the immediate molecular impacts of traumatic brain injuries (TBIs) using an innovative proteomics method. By simulating TBIs in the lab, researchers discovered significant changes to the neuronal proteome and introduced a new proteome-based 'shock meter' to assess cell damage.

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