ChemistryCommunications Chemistry
Mapping protein binding sites by photoreactive fragment pharmacophores
P. Ábrányi-balogh, D. Bajusz, et al.
This exciting research, conducted by a team including Péter Ábrányi-Balogh and Zoltán Orgován, presents a novel screening approach that integrates evolutionary optimized fragment pharmacophores with a photoaffinity handle, yielding high hit rates through LC-MS detection. Enhanced by a target-conjugated photocatalyst, this study reveals many fragment hits across six protein targets, showcasing impressive performance over traditional drug discovery methods.
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