Chemistry

Mapping protein binding sites by photoreactive fragment pharmacophores

P. Ábrányi-balogh, D. Bajusz, et al.

This exciting research, conducted by a team including Péter Ábrányi-Balogh and Zoltán Orgován, presents a novel screening approach that integrates evolutionary optimized fragment pharmacophores with a photoaffinity handle, yielding high hit rates through LC-MS detection. Enhanced by a target-conjugated photocatalyst, this study reveals many fragment hits across six protein targets, showcasing impressive performance over traditional drug discovery methods.