Psychology

Longitudinal hippocampal subfield development associated with psychotic experiences in young people

A. O'neill, N. Dooley, et al.

This study delves into the intriguing changes in hippocampal subfields among adolescents with sub-threshold psychotic experiences. With insights from authors including Aisling O'Neill and Niamh Dooley, discover how the brain's architecture may differ between those experiencing psychotic symptoms and healthy controls over a six-year span.

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Playback language: English

Index

Abstract

This study investigated the longitudinal trajectory of hippocampal subfields in adolescents experiencing sub-threshold psychotic experiences (PE). 211 young people (11-13 years) participated initially; 78 with at least one scan were included (33 PE, 45 controls). Neuroimaging occurred at three timepoints over six years. Linear Mixed Effects analyses revealed that before correction, subfield volumes increased in the control group and decreased in the PE group for the right CA2 and CA2/3 subfields (large effect sizes). Reduced right subiculum and left presubiculum volumes were observed in the PE group compared to controls. However, none of these effects survived correction for multiple comparisons. Symptom severity was not associated with subfield volumes. These findings offer insight into hippocampal subfield abnormalities in psychotic experiences.

Publisher

Translational Psychiatry

Published On

Jan 20, 2024

Authors

Aisling O'Neill, Niamh Dooley, Darren Roddy, Colm Healy, Eleanor Carey, Thomas Frodl, Erik O'Hanlon, Mary Cannon

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