Medicine and Health

Fitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study

I. Maurus, L. Roell, et al.

This intriguing study explores the relationship between aerobic fitness and hippocampal formation volume in schizophrenia. Conducted by Isabel Maurus and colleagues, it highlights significant positive associations between fitness levels and various HF subfields, suggesting aerobic exercise could help mitigate volume loss in the brain regions most affected by the disorder.

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Abstract

Hippocampal formation (HF) volume loss is a well-established finding in schizophrenia. This study investigated potential associations between aerobic fitness and HF subfield structure, functional connectivity, and related cognitive impact. Significant positive associations between aerobic fitness levels and volumes were demonstrated for most HF subfields, with the strongest associations for the cornu ammonis, dentate gyrus, and subiculum. No significant associations were found for HF functional connectivity or mediation effects on verbal memory. Aerobic fitness may mitigate HF volume loss, especially in the subfields most affected in schizophrenia. This finding should be further investigated in longitudinal studies.

Publisher

Translational Psychiatry

Published On

Sep 16, 2022

Authors

Isabel Maurus, Lukas Roell, Daniel Keeser, Boris Papazov, Irina Papazova, Moritz Lembeck, Astrid Roeh, Elias Wagner, Dusan Hirjak, Berend Malchow, Birgit Ertl-Wagner, Sophia Stoecklein, Alkomiet Hasan, Andrea Schmitt, Andreas Meyer-Lindenberg, Peter Falkai

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