Medicine and Health

Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets

G. Kenny, L. Townsend, et al.

This review delves into Long COVID, a complex clinical syndrome marked by lingering symptoms post-SARS-CoV-2 infection. It investigates multiple symptom manifestations, potential causes such as immune dysregulation, and emphasizes the necessity for collaborative research efforts to enhance treatment and understanding of this multifaceted condition. This research was conducted by Grace Kenny, Liam Townsend, Stefano Savinelli, and Patrick W G Mallon.

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Index

Abstract

This review examines Long COVID, a clinical syndrome characterized by persistent symptoms after SARS-CoV-2 infection. It outlines the wide range of symptoms, explores leading hypotheses about its pathophysiology (including immune dysregulation, viral persistence, autoimmunity, microbiome dysbiosis, dysautonomia, and endotheliopathy), identifies research gaps, and discusses potential therapeutic targets and future research directions. The heterogeneity of Long COVID poses significant challenges to research, emphasizing the need for a coordinated international effort to improve understanding and treatment.

Publisher

Frontiers in Molecular Biosciences

Published On

Oct 26, 2023

Authors

Grace Kenny, Liam Townsend, Stefano Savinelli, Patrick W G Mallon

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