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Abstract
This study investigated the mechanism by which L-valine stimulates glucagon-like peptide 1 (GLP-1) release. Oral L-valine increased plasma active GLP-1 in mice comparably to glucose. In isolated perfused rat small intestine, L-valine strongly stimulated GLP-1 release, an effect inhibited by nifedipine (voltage-gated Ca²⁺-channel blocker) and diazoxide (KATP-channel opener). L-valine also stimulated GLP-1 and PYY release from the perfused rat colon, though less potently than in the small intestine. The findings suggest that L-valine's GLP-1 stimulatory effect involves intracellular metabolism, KATP-channel closure, and voltage-gated Ca²⁺-channel opening.
Publisher
Nutrition and Diabetes
Published On
Jun 11, 2024
Authors
Ida Marie Modvig, Mark M. Smits, Katrine Douglas Galsgaard, Anna Pii Hjørne, Anna Katarzyna Drzazga, Mette Marie Rosenkilde, Jens Juul Holst
Tags
L-valine
GLP-1
metabolism
ca²⁺ channels
KATP channels
intestinal stimulation
PYY

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