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Kinesin-1 activity recorded in living cells with a precipitating dye

Biology

Kinesin-1 activity recorded in living cells with a precipitating dye

S. Angerani, E. Lindberg, et al.

Discover a groundbreaking fluorogenic small molecule substrate, QPD-OTf, designed for kinesin-1, an essential motor protein for intracellular cargo transport. This innovative substrate enables visualization of kinesin-1's activity in live cells without any modifications, showcasing its path as it moves from the Golgi along microtubules. This exciting research was conducted by Simona Angerani, Eric Lindberg, Nikolai Klena, Christopher K. E. Bleck, Charlotte Aumeier, and Nicolas Winssinger.

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