Ketamine activates adult-born immature granule neurons to

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Abstract

Ketamine's rapid antidepressant effects are mediated by adult-born immature granule neurons (ABINs) in the mouse hippocampus. Ketamine activates ABINs, and chemogenetic inhibition of ABINs blocks ketamine's antidepressant effects. Conversely, chemogenetic ABIN activation mimics ketamine's cellular and behavioral effects. This identifies ABINs as a potential therapeutic target for depression.

Publisher

Nature Communications

Published On

Nov 16, 2022

Authors

Radhika Rawat, Elif Tunc-Ozcan, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler

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