logo
ResearchBunny Logo
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

Medicine and Health

Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

R. Rawat, E. Tunc-ozcan, et al.

Explore the exciting discovery that ketamine's rapid antidepressant effects are driven by adult-born immature granule neurons (ABINs) in the mouse hippocampus. Research by Radhika Rawat, Elif Tunc-Ozcan, Tammy L. McGuire, Chian-Yu Peng, and John A. Kessler uncovers how activating and inhibiting these neurons could lead to new depression therapies.

00:00
Playback language: English
Abstract
Ketamine's rapid antidepressant effects are mediated by adult-born immature granule neurons (ABINs) in the mouse hippocampus. Ketamine activates ABINs, and chemogenetic inhibition of ABINs blocks ketamine's antidepressant effects. Conversely, chemogenetic ABIN activation mimics ketamine's cellular and behavioral effects. This identifies ABINs as a potential therapeutic target for depression.
Publisher
Nature Communications
Published On
Nov 16, 2022
Authors
Radhika Rawat, Elif Tunc-Ozcan, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler
Tags
Ketamine
depression
ABINs
hippocampus
antidepressant effects
chemogenetic activation
mice

Related Publications

Explore these studies to deepen your understanding of the subject.

Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
Medicine and Health

Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice

E. Siopi, M. Galerne, et al.

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Medicine and Health

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

G. Chevalier, E. Siopi, et al.

Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression
Medicine and Health

Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

J. Kopelman, T. A. Keller, et al.

Music prevents stress-induced depression and anxiety-like behavior in mice
Medicine and Health

Music prevents stress-induced depression and anxiety-like behavior in mice

Q. Fu, R. Qiu, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny