This study investigated the relationship between interoception and two factors underlying social cognition: self-other boundary and sensitivity to social cues. Interoceptive accuracy (IAc), measured by a heartbeat perception task, was correlated with spontaneous facial mimicry (SFM) frequency only in the direct gaze condition. The eye contact effect on SFM (difference in SFM between direct and averted gaze) was positively correlated with IAc. These findings suggest interoception's role in social cue sensitivity and potentially in self-other boundary modulation by social context.