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Interface potential-induced natural antioxidant mimic system for the treatment of Alzheimer’s disease

Medicine and Health

Interface potential-induced natural antioxidant mimic system for the treatment of Alzheimer’s disease

K. Liu, Q. Ding, et al.

This groundbreaking research, conducted by Kangning Liu and colleagues, presents a revolutionary synergistic antioxidant treatment for Alzheimer's disease, combining a metal-organic framework with superoxide dismutase activity and curcumin. Their innovative system enhances cognitive function in AD mice by improving both antioxidant capacity and plaque scavenging. Discover the exceptional potential of this treatment!

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Playback language: English
Abstract
This research introduces a novel synergistic antioxidant treatment system for Alzheimer's disease (AD) using a metal-organic framework (MOF, ZnBTC) with superoxide dismutase (SOD) activity and curcumin (non-enzymatic antioxidant). The system leverages the complementary surface electrostatic potential between ZnBTC and curcumin to enhance both antioxidant activity and β-amyloid plaque scavenging ability, improving cognitive function in AD mice.
Publisher
Communications Chemistry
Published On
Authors
Kangning Liu, Qi Ding, Doudou Cao, Enpeng Xi, Yun Zhao, Nan Gao, Yajie Yang, Ye Yuan
Tags
Alzheimer's disease
antioxidant treatment
metal-organic framework
superoxide dismutase
curcumin
cognitive function
β-amyloid plaque

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