This study investigated the predictive value of neuropsychiatric symptoms (NPS) and APOE ε4 status on the conversion to dementia in Mild Cognitive Impairment (MCI) patients. 1512 MCI patients were followed for a mean of 2 years. Additive interactions between several NPS (depression, apathy, anxiety, agitation, appetite, irritability) and APOE ε4 significantly increased the hazard ratios of incident dementia. The combination of NPS and APOE ε4 status could help identify MCI patients at highest risk of dementia conversion.
Publisher
Scientific Reports
Published On
Nov 18, 2020
Authors
Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montreal, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruíz
Tags
neuropsychiatric symptoms
APOE ε4
dementia
Mild Cognitive Impairment
predictive value
hazard ratios
risk assessment
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