This study globally assessed the prevalence of insomnia and daytime sleepiness among college students and their quality of life (QoL), considering different developmental levels and a period before the COVID-19 pandemic. A survey involving 20,139 students from 60 countries used the Athens Insomnia Scale (AIS), Epworth Sleepiness Scale (ESS), and Manchester Short Assessment of QoL (MANSA). Results showed high prevalence of insomnia (57.6%) and daytime sleepiness (27.0%), with women, low-income students, and non-medical students at higher risk of insomnia. Both sleepiness conditions significantly reduced QoL. The COVID-19 pandemic increased insomnia risk. Students in high GDP per capita countries had lower insomnia risk. Sleep disorders negatively impacted students' QoL.