This study investigated the neural response to food cues in obese endometrial cancer survivors seeking weight loss, categorized by obesity class (I/II and III). Using fMRI, researchers measured brain activation in response to high-calorie vs. non-food images in fasted and fed states. Class III obesity showed significantly higher dorsolateral prefrontal cortex (DLPFC) activation and lower insula activation in the fasted state compared to Class I/II. Increased DLPFC activation persisted in both groups in the fed state. Findings suggest targeting DLPFC in weight loss interventions, particularly for severe obesity.
Publisher
Nutrition and Diabetes
Published On
Jun 15, 2020
Authors
Nora L. Nock, Huangqi Jiang, Lauren Borato, Jay Alberts, Anastasia Dimitropoulos
Tags
obesity
endometrial cancer
fMRI
brain activation
weight loss
DLPFC
food cues
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