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Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

Medicine and Health

Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

K. M. Garske, A. Kar, et al.

This study investigates the intriguing link between increased body mass index (BMI) and chromatin co-accessibility changes in human preadipocytes, revealing how obesity might drive inflammation. Conducted by a team of experts including Kristina M. Garske and Jaakko Kaprio, the research uncovers potential mechanisms through which obesity may contribute to systemic inflammation.

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Playback language: English
Abstract
Obesity-induced adipose tissue dysfunction can cause low-grade inflammation and downstream obesity comorbidities. This study used human primary preadipocytes from body mass index (BMI)-discordant monozygotic (MZ) twin pairs to investigate whether increased BMI alters chromatin co-accessibility, leading to inflammation. Results show altered co-accessibility in higher BMI twins for a large genomic region (~88.5 Mb), linking these regions to systemic inflammation through interactions with BMI and C-reactive protein (CRP). Open chromatin co-accessibility in preadipocytes is disrupted in higher BMI individuals, suggesting a mechanism linking obesity to inflammation via gene-environment interactions.
Publisher
Nature Communications
Published On
Jul 14, 2023
Authors
Kristina M. Garske, Asha Kar, Caroline Comenho, Brunilda Balliu, David Z. Pan, Yash V. Bhagat, Gregory Rosenberg, Amogha Koka, Sankha Subhra Das, Zong Miao, Janet S. Sinsheimer, Jaakko Kaprio, Kirsi H. Pietiläinen, Päivi Pajukanta
Tags
Obesity
Adipose tissue
Chromatin co-accessibility
Inflammation
Gene-environment interactions
C-reactive protein
Preadipocytes

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