Biology

Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?

S. Aherfi, D. B. Belhaouari, et al.

This groundbreaking study by Sarah Aherfi and colleagues reveals surprising insights into Pandoravirus massiliensis, challenging the conventional understanding of viruses. A proton gradient was detected along with a unique enzyme related to energy production, calling into question long-held definitions of viral entities. Explore the implications of this discovery!

00:00

Playback language: English

Index

Abstract

The discovery of giant viruses has challenged the traditional definition of viruses. This study investigated energy production in Pandoravirus massiliensis. A membrane potential was detected in purified virions, enhanced by acetyl-CoA and abolished by CCCP. Bioinformatics identified eight putative P. massiliensis proteins with low sequence identity to TCA cycle enzymes; one, ORF132, functioned as isocitrate dehydrogenase. The presence of a proton gradient raises questions about the definition of a virus.

Publisher

The ISME Journal

Published On

Authors

Sarah Aherfi, Djamal Brahim Belhaouari, Lucile Pinault, Jean-Pierre Baudin, Philippe Decloquement, Jonatas Abrahão, Philippe Colson, Anthony Levasseur, David C. Lamb, Eric Chabrière, Didier Raoult, Bernard La Scola

Related Publications

Explore these studies to deepen your understanding of the subject.

Psychology

Diet, gym, supplements, or maybe it is all in your mind? A systematic review and meta-analysis of studies on placebo and nocebo effects in weight loss in adults

Ł. Kryst, P. Bąbel, et al.

Medicine and Health

Nighttime Acid Reflux in Gastroesophageal Reflux Disease -Is It a Problem That Can Be Solved?

Y. Choi and C. M. Shin

Political Science

A rather wild imagination: who is and who is not a migrant in the Czech media and society?

M. G. Bartoszewicz and O. Eibl

Interdisciplinary Studies

Expertise in research integration and implementation for tackling complex problems: when is it needed, where can it be found and how can it be strengthened?

G. Bammer, M. O'rourke, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny