logo
ResearchBunny Logo
In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

Medicine and Health

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

A. Launay, C. Wu, et al.

Discover the fascinating adaptive evolution of *Bordetella hinzii*, a zoonotic pathogen, in a patient with interleukin-12 receptor β1 deficiency. Researchers A. Launay, C.-J. Wu, A. Dualanto Chiang, J.-H. Youn, P. P. Khil, and J. P. Dekker reveal how genomic changes led to significant diversification and metabolic adaptations in the pathogen, highlighting the influence of the host's immune response on evolution after zoonotic infections.

00:00
00:00
Playback language: English
Abstract
This study characterizes the adaptive evolution of the zoonotic pathogen *Bordetella hinzii* within a patient with interleukin-12 receptor β1 deficiency. Genomic sequencing of 24 isolates revealed extensive within-host diversification, driven by an E96 substitution in the DNA polymerase III ε-subunit, causing proofreading deficiency. This led to mutations in DNA repair genes, altered mutational spectra, and metabolic adaptations. An excess of G:C > T:A transversions suggested oxidative stress. The study highlights the role of host immune phenotype in shaping pathogen evolution post-zoonotic infection.
Publisher
Nature Communications
Published On
Jul 23, 2021
Authors
A. Launay, C.-J. Wu, A. Dualanto Chiang, J.-H. Youn, P. P. Khil, J. P. Dekker
Tags
Bordetella hinzii
zoonotic pathogen
genomic sequencing
mutational spectra
oxidative stress
host immune phenotype
adaptive evolution

Related Publications

Explore these studies to deepen your understanding of the subject.

Evolution of the SARS-CoV-2 spike protein in the human host
Medicine and Health

Evolution of the SARS-CoV-2 spike protein in the human host

A. G. Wrobel, D. J. Benton, et al.

Reshaping energy policy based on social and human dimensions: an analysis of human-building interactions among societies in transition in GCC countries
Environmental Studies and Forestry

Reshaping energy policy based on social and human dimensions: an analysis of human-building interactions among societies in transition in GCC countries

A. Ghofrani, E. Zaidan, et al.

A potential therapeutic strategy of an innovative probiotic formulation toward topical treatment of diabetic ulcer: an in vivo study
Medicine and Health

A potential therapeutic strategy of an innovative probiotic formulation toward topical treatment of diabetic ulcer: an in vivo study

F. Karimi, N. Montazeri-najafabady, et al.

Studying the impact of profitability, bankruptcy risk, and pandemic on narrative tone in annual reports in an emerging market in the East
Business

Studying the impact of profitability, bankruptcy risk, and pandemic on narrative tone in annual reports in an emerging market in the East

B. T. H. Le and C. V. Nguyen

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny