Medicine and Health

A potential therapeutic strategy of an innovative probiotic formulation toward topical treatment of diabetic ulcer: an in vivo study

F. Karimi, N. Montazeri-najafabady, et al.

Discover the promising results of a revolutionary oleogel-based probiotic formulation aimed at treating diabetic ulcers, showcasing the exceptional healing capabilities of *L. acidophilus* and *L. rhamnosus*. This groundbreaking research by Farkhonde Karimi and colleagues highlights a potential alternative treatment that could change how diabetic ulcers are approached in clinical settings.

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Abstract

This in vivo study investigated the potential of a novel oleogel-based probiotic formulation for treating diabetic ulcers (DUs). Four Lactobacillus species (*L. rhamnosus*, *L. casei*, *L. fermentum*, and *L. acidophilus*) were individually incorporated into the formulation. *L. acidophilus* and *L. rhamnosus* demonstrated the most significant wound-healing potential, exhibiting increased hydroxyproline content, fibroblast density, collagen fibrils, and neovascularization compared to tetracycline and control groups. *L. rhamnosus* also showed significant biofilm inhibition activity against common pathogens. The findings suggest this probiotic formulation, particularly those containing *L. acidophilus* and *L. rhamnosus*, holds promise as an alternative treatment for DUs, warranting further clinical trials.

Publisher

Nutrition and Diabetes

Published On

Aug 20, 2024

Authors

Farkhonde Karimi, Nima Montazeri-Najafabady, Fatemeh Mohammadi, Amir Azadi, Farhad Koohpeyma, Ahmad Gholami

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