Impact of COVID-19 on Pregnancy Outcomes across Trimesters in the United States

This study utilized the National Inpatient Sample (NIS) database to investigate trimester-specific outcomes among hospitalized pregnant women diagnosed with COVID-19. Higher in-hospital mortality rates were observed in the third trimester for COVID-19 patients compared to those without the virus. Rates of mechanical ventilation, acute kidney injury, renal replacement therapy, and perinatal complications (preeclampsia, HELLP syndrome, and preterm birth) were significantly elevated across all trimesters for COVID-19 patients. COVID-19 was more prevalent among low-income, Hispanic pregnant women. The findings highlight the increased risk of maternal mortality and complications associated with COVID-19 during pregnancy, particularly in the third trimester, and emphasize the need for equitable healthcare strategies to reduce adverse maternal and fetal outcomes.

Shiza Virk, Karthik Gan, Adeel Nasrullah, Aaisha Shah, Zohaa Faiz, Umair Khan, David Bradley Jackson, Anam Javed, Asif Farooq, Briana Disilvio, Tariq Cheema, Abu Baker Sheikh